JesJoint

Description

JESJOINT Caplet:  For total joint care

• Glucosamine sulfate potassium chloride
• Methylsulfonylmethane (MSM)
• Grape seed extract
• Boswellia extract
• Turmeric extract
• Boron amino acid chelate
• Vitamin A
• Chondroitin sulfate sodium

JESJOINT is an innovative dietary supplement for joint health and a safer and effective treatment for osteoarthritis. It presents both symptom-modifying and structure-modifying effects and has the added advantage of an improved safety profile.

Key benefits

• Reduces joint-related aches, pains and discomfort for people with osteoarthritis.
• Supports the repair and maintenance of joint cartilage, by stimulating cartilage cells (chondrocytes) to produce glycosaminoglycans and proteoglycans.
• Slows the breakdown of joints and prevent the osteoarthritis from getting worse. Some research shows that people who take JESJOINT might be less likely to need total knee replacement surgery.
• Increases strength in the joints by promoting the formation of strong cartilage.
• Improves the lubricant properties of synovial fluid thereby facilitating joint mobility and flexibility.
• Improves overall physical function and quality of life.
• Has anti-inflammatory properties that help relieve joint stiffness and reduce joint swelling.
• Reduces or eliminates NSAID use.

Composition
Each JESJOINT Caplet contains
Glucosamine sulfate potassium chloride: 750 mg
Methylsulfonylmethane (MSM): 250 mg
Grape seed extract: 25 mg
Boswellia extract: 75 mg
Turmeric extract: 12.5 mg
Boron amino acid chelate: 20 mg
Vitamin A: 250 IU
Chondroitin sulfate: 50 mg

Glucosamine sulfate potassium chloride
Glucosamine is a naturally occurring amino monosaccharide and a normal constituent of glycosaminoglycans in the articular cartilage and synovial fluid.

Pharmacodynamics
Glucosamine is used by chondrocytes in the biosynthesis of proteoglycans and glycosaminoglycans, which are the building blocks of the joint cartilage.
It inhibits breakdown of articular cartilage possibly through its anti-inflammatory properties. Glucosamine has been shown to reduce the levels of pro-inflammatory factors (such as tumour necrosis factor-alpha, interleukin-1, and interleukin-6) and their joint-degenerating effects (1, 2)
Methylsulfonylmethane
Methylsulfonylmethane (MSM) is a naturally occurring organosulfur compound found naturally in some plants and it is added in small amounts to many foods and beverages as a dietary supplement.

Pharmacodynamics
Due to its rich sulfur content, MSM is used by the body to maintain normal connective tissue including joint cartilage.
MSM exerts antiinflammatory activities in the joints through suppressive effects on pro-inflammatory cytokines such as IL-1β and TNF-α.
It has been reported that MSM can reduce joint-related pain by blocking the pain response in nerve fibers (4)

Grape seed extract
Grape seed extract (GSE) is a dietary supplement made from the bitter-tasting seeds of grape fruit.
It is rich in compounds with powerful antioxidant and anti-inflammatory properties, including oligomeric proanthocyanidin complexes (OPCs), polyphenols, vitamin E, anthocyanins and flavonoids.

Pharmacodynamics
GSE protects articular cartilage through the inhibition of pro-inflammatory pathways as well as reduction of oxidative stress. Grape seed proanthocyanidin has been reported to decrease perichondrial inflammation and alveolar bone loss by decreasing MMPs, oxidative stress and pro-inflammatory cytokines (hypoxia-inducible factor 1-alpha, TNF-α, and IL-17) levels, and increasing osteoblastic activity (5).

Boswellia extract
Boswellia extract, also known as Indian frankincense, is an herbal extract sourced from the Boswellia serrata tree. It’s main active ingredient is the boswellic acid.

Pharmacodynamics
Clinical studies have shown that Boswellia extract has anti-inflammatory and anti-arthritis properties, that help to improve pain and physical function in people with osteoarthritis.
Boswellic acids are powerful inhibitors of 5-lipoxygenase (5-LOX), an enzyme that produces the pro-inflammatory molecule leukotriene (6).

Turmeric extract
Turmeric is an herbal extract produced from the rhizome (underground stem) of the Turmeric plant.
Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a polyphenol, is the active ingredient in turmeric, and it has powerful pharmacological properties.

Pharmacodynamics
It has powerful anti-inflammatory and anti-oxidant effects, which explain most of the health benefits of turmeric extract. Curcumin has been shown to suppress pro-inflammatory cytokines and scavenge different forms of free radicals through many different mechanisms.
It is reputed to relieve joint pain and swelling from arthritis. One study noted that turmeric extract resulted in similar improvements in arthritis symptoms (mainly pain and inflammation-related symptoms) as paracetamol, ibuprofen and diclofenac sodium (7, 8).

Boron amino acid chelate
Boron amino acid chelate is a dietary supplement of boron – a trace mineral that is naturally present in many foods and available as a dietary supplement.

Pharmacodynamics
Multiple clinical studies in humans suggests that boron may help alleviate the symptoms of osteoarthritis, possibly by reducing inflammation and oxidative stress.
It has been proven to reduce levels of inflammatory biomarkers, such as hs-CRP and TNF-α, raise the level of endogenous antioxidant enzymes including SOD, catalase and glutathione peroxidase, and promote the growth and maintenance of healthy bones (9).

Vitamin A
Vitamin A is a fat-soluble vitamin that is naturally present in many foods.

Pharmacodynamics
Vitamin A has been shown to have bone-protecting effects when intake either from diet or supplementation is within the recommended daily limit. It stimulates osteoblastic activity and bone formation and inhibits osteoclastic activity and bone resorption.
Chondroitin sulfate sodium
Chondroitin sulfate is a compound present naturally in the body as an essential part of hyaline cartilage.
It is a sulfated glycosaminoglycan composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).
Pharmacodynamics
Chondroitin sulfate is a major component of the extracellular matrix (ECM) of many connective tissues, including cartilage, bone, skin, ligaments and tendons.
It provides the building blocks for the synthesis of new matrix component thereby promoting matrix regeneration.
Chondroitin sulfate is responsible for many of the important biome-chanical properties of the human cartilage – it provides much of its resistance and elasticity. It plays a major role in allowing cartilage to resist pressure stresses during various loading conditions.
Many studies have reported other effects of chondroitin sulfate including anti-inflammatory, anticatabolic, anti-apoptotic, and anti-oxidant properties (10).

JESJOINT in guidelines
Based on the data published in many clinical trials, the Osteoarthritis Research Society International (OARSI) and the European League Against Rheumatism (EULAR) have recommended the use of glucosamine sulfate and chondroitin sulfate for the management of osteoarthritis {3, 10, 11).
Both organizations recognized the symptomatic and structure-modifying effects of the two compounds in people with osteoarthritis.
Glucosamine sulfate and chondroitin sulfate are active ingredients in JESJOINT.

Indications/uses of JESJOINT
JESJOINT is indicated in the management of the following:
• Osteoarthritis
• Rheumatoid arthritis
• Temporomandibular joint disorder
• Osteoporosis
• Chronic lower back pain
• Lumbar spondylosis
• In any other conditions of joint discomfort or cartilage damage

Suggested dosage
Adults and elderly
One JESJOINT caplet daily with a meal.

Adverse effects
The active ingredients in JESJOINT have long well-established safety record when taken at the recommended dosage.
Common side effects may include nausea, diarrhea and gastrointestinal upset.
Do not exceed the recommended dosage.

Contraindications
JESJOINT is contraindicated in pregnancy and breast feeding mothers, allergy to shellfish, grape allergies and gall stones.