HipotB

Description

HipotB

Essential phospholipids (polyunsaturated phosphatidylcholine) 300 mg + silymarin 140 mg + multivitamins.

HipotB is a herbal formula packed with 2 natural compounds with well-documented and powerful hepatoprotective properties – essential phospholipids (polyunsaturated phosphatidylcholine) and silymarin. As a result, HipotB gives your patients unrivalled hepatoprotection (compared to its competitors which contains just either one of the 2 compounds). HipotB also contains multivitamins that help promote liver health and overall well-being. For its potency and efficacy in protecting the liver, HipotB has earned the name the Defender of the liver.

Composition

Each soft gelatin capsule contains:

Essential phospholipids (polyunsaturated phosphatidylcholine)

• Essential phospholipids (EPL) is a highly purified extract of soybean.
• The main active ingredient is the polyunsaturated phosphatidylcholine (PPC) molecules.
• Phospholipids form the lipid bilayer which is the structural basis of cellular and subcellular membranes and is critical for their fluidity and biological activity.

Key benefits

• Improves symptoms and clinical status of patients with liver disease of various origins
• Improves liver structure – as shown by imaging findings and histology.
• Improves liver function – as shown by reduction in transaminase levels and improvements in other biochemical parameters.
• Improves non-alcoholic fatty liver disease (NAFLD) associated hyperlipidemia – reduces triglycerides and cholesterol levels

Pharmacodynamics

EPL has the ability to get incorporated into damaged sections of hepatocytes cell membranes and produce the following evidence-based effects:

• Promotes cell membrane repair
• Promotes hepatic regeneration
• Increase cell membrane fluidity and functionality – by increasing the amount of PPC in membranes
• Protects cell membranes
• Inhibits liver steatosis – it reduces leptin secretion and reduces lipid accumulation in the liver
• EPL has proven antioxidant and anti-inflammatory effects
• Anti-fibrotic effects – it reduces liver fibrosis and cirrhosis by stabilizing the membranes, inhibiting hepatic stellate cells and activation of collagenase enzymes
• Inhibits lipid peroxidation
• Anticholestatic effects – through improved bile stabilisation and membranes fluidity occasioned by increased PPC.

Silymarin

Silymarin is a natural compound that is extracted from the the dried seeds and fruits of Milk thistle (scientific name = Silybum marianum). It is composed of a mixture of four isomeric flavonolignans: silibinin (the most prevalent and biologically active component), isosilibinin, silydianin and silychristin. These compounds are known to be antioxidants in addition to having several other biologic properties.

Key benefits

• Improves liver-related symptoms and quality of life
• Improves liver function as demonstrated by reduction in liver enzyme levels
• Improves liver structural and histologic parameters
• Reduces liver-related mortality in patients with cirrhosis
• Improves glycemic control in patients with concomitant diabetes

Pharmacodynamics

• Animal and human studies demonstrate that silibinin is a potent scavenger of free radicals.
• Augments the generation of glutathione in the liver via an increase in substrate availability (i.e. cysteine) for its biosynthesis (glutathione is the body’s endogenous master antioxidant)
• Binds to cell membranes to suppress toxin penetration into hepatocytes
• It stabilizes membrane permeability through inhibition of lipid peroxidation
• Anti-inflammatory effects – by inhibiting inflammatory mediators such as NF-κB and inflammatory metabolites (e.g., prostaglandin E2 [PGE2] and leukotriene B4 [LTB4])
• Stimulates regeneration of damaged hepatocytes by increasing protein synthesis
• Antifibrogenic effects – by inhibiting the production of pro-collagen in activated human hepatic stellate cells.
• Reduces insulin resistance in diabetic patients with liver cirrhosis

Multivitamins

B-vitamins are water soluble vitamins which are naturally present in some foods, added to some food products, and available as a dietary supplement.
Vitamin E refers to a group of structurally related, fat-soluble, plant-derived compounds with distinctive antioxidant properties. Vitamin E acetate is a specific form of vitamin E.

Key benefits

Taking multivitamin supplements can prevent or reverse the nutritional deficiencies that often develop in people with liver disease.
Vitamin E is widely recognised as a potent chain-breaking antioxidant with hepatoprotective activity demonstrated in both animal and human studies.

Indications

• Acute viral hepatitis
• Adjuvant therapy in chronic viral hepatitis – Chronic hepatitis B and C infections
• Alcoholic liver disease – alcohol-induced fatty liver (steatosis), alcoholic steatohepatitis (ASH)
• Non-alcoholic Fatty Liver Disease (NALFD) – non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH)
• Hepatitis induced by drugs or toxins – e.g., prevention and treatment of chemotherapy-induced liver disease
• Adjuvant therapy in liver cirrhosis
• Prophylaxis of recurrent gallstone

Dosage

Adults and children over 12 years: one soft gel 2 to 3 times a day with main meal or as directed by the physician.

One important finding observed in most of the clinical studies reviewed was that the benefits of HipotB may reduce once treatment is stopped. So healthcare providers should consider uninterrupted maintenance therapy to avoid relapse.

Adverse reactions

HipotB is generally very well tolerated, with a low incidence of adverse events and no treatment-related serious adverse effects.